Muscle contractions are initiated by depolarization of the voltage across the plasma membrane resulting from synaptic release at the neuromuscular junction (NMJ). Excitation–contraction (EC) coupling ...

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly progressive course.

- Muscle cells, also known as myocytes, are specialized cells designed for contraction and force production. Skeletal Muscle Cells: These cells are long, cylindrical, and have a striated (or striped) ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...