Khan Academy

Attenuation of trp operon transcription is controlled by - Sanders 3rd Edition Ch 12 Problem 15

🧬 Trp Operon Hack: Why "Low" means "Go!" 🚀 Ever get confused about which stem-loop forms when? Let's simplify Attenuation! 🧠💡 In the Trp Operon, the leader peptide sequence acts as a sensor. Here is exactly what happens when Tryptophan is LOW (as shown in the graphic): 1️⃣ The Stall: The Ribosome attempts to translate the leader peptide but gets stuck at the Trp codons because there isn't enough charged tRNA-Trp available. 2️⃣ The Pairing: Because the ribosome is stalled at region 1, region